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Scientists create mice with cells from two males for the first time

For the first time, scientists have created baby rats from two males.

This raises the distant possibility of using the same technology in humans, but experts say that few mouse embryos have grown into live mouse offspring, and no one knows if it will work in humans. I am warning you.

Still, “it’s a very clever strategy,” said Diana Laird, a stem cell and reproductive expert at the University of California, San Francisco. “This is an important step in both stem cell and reproductive biology.”

Scientists described their research in a study published in the journal Wednesday Nature.

First, they took skin cells from the tails of male mice and converted them into induced pluripotent stem cells. These stem cells can develop into different types of cells and tissues. Then, through a process of growing them and treating them with drugs, they transformed the male mouse stem cells into female cells and generated functional eggs. Finally, the eggs were fertilized and the embryos transferred to female mice. About 1% (7 out of 630) of the embryos developed into live mouse pups.

The puppies appeared to be growing normally and were able to parent in the normal way, said Katsuhiko Hayashi, research leader at Kyushu University and Osaka University in Japan, at the 3rd International Conference on Human Genome Editing last week. told a fellow scientist at the summit.

In a comment published with Nature According to the study, Laird and her colleague Jonathan Bayerl say the work “opens new avenues for the study of reproductive biology and fertility” in animals and humans. For example, in the future it may be possible to breed endangered mammals from her single male.

“And it may provide a template for allowing more people, such as male same-sex couples, to have biological children while avoiding the ethical and legal issues of egg donors. they wrote.

However, they did draw some attention. Most notably: This technique is highly inefficient. They said it was unclear why only a fraction of the embryos transferred to the surrogate mice survived. The reason may be technical or biological. They also emphasized that it is still too early to know if the protocol works with human stem cells.

Laird also said scientists should be aware of any mutations or errors that may be introduced into the culture dish before using stem cells to make eggs.

This study is the latest to test a new method of creating mouse embryos in the laboratory. Last summer, scientists in California and Israel created “synthetic” mouse embryos from stem cells, without using the father’s sperm or the mother’s eggs or uterus. These embryos mirrored natural mouse embryos up to eight and a half days after fertilization and contained the same structures, including something like a beating heart. The scientists said the feat could eventually lay the groundwork for creating synthetic human embryos for future research.

https://www.voanews.com/a/scientists-create-mice-with-cells-from-2-males-for-first-time/7007113.html Scientists create mice with cells from two males for the first time

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