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U.S. officials are watching carefully for the “Delta Plus” mutation to spread to the UK

Dr. Rochelle Walensky, director of the Centers for Disease Control and Prevention, testifies at a hearing of the Senate Health, Education and Labor Pensions Committee held at the US Capitol on May 11, 2021.

Jim Lo Skalzo | Pool | Reuters

US health officials are paying attention to a new Covid-19 subvariant called “Delta Plus.” Some scientists say it may be more contagious than the already infectious delta variants.

Delta Plus, officially known as AY.4.2, contains two new mutations to the spek protein, A222V and Y145H, which allow the virus to enter the body. Since these mutations have been found in other Covid mutants, it is unclear how dramatic these changes will affect the virus.

According to the center, François Barrow, director of the Institute of Genetics at University College London, first appeared in India and was more than 10% more contagious than Ebola, SARS, MERS, and Delta, which is more susceptible to the 1918 Spanish flu. He said he could. For disease control and prevention.

According to CDC director Dr. Rochelle Walensky, Delta’s R-naught or fertility is 8 or 9, which means that everyone with Covid will spread it to up to 9 others. To do. Covid’s “wild-type” or original strain had an estimated R-naught of about 3. People infected with the delta mutant have 1,000 times the viral load of the original Covid strain.

The Indian Ministry of Health reported in June that DeltaPlus is more contagious than Delta mutants, and subtypes may even bind more strongly to lung cell receptors, reducing the effectiveness of monoclonal antibody therapy. I added.

CDC director Rochelle Walensky said in a briefing at the White House Covid on Wednesday that the mutation was detected in the United States but did not show a noticeable increase in Delta Plus cases across the country.

“In particular, we are monitoring sub-strains that may affect treatments such as monoclonal antibodies and vaccines,” Warensky said. “At this time, there is no evidence that subline AY.4.2 affects the efficacy of current vaccines or treatments.”

According to Outbreak.info, the AY.4.2 subvariant has been detected in at least five cases in the United States since August. We collect data from GISAID, a global database in Washington, DC, California, North Carolina, Washington, and Massachusetts. Genome data on Covid and influenza cases worldwide.

Leading health authorities are fueled by billions of people around the world who remain unvaccinated, resulting in stronger and potentially vaccine-resistant Covid mutants as long as widespread outbreaks continue to occur. I’ve been warning you for a few weeks that it’s possible. Dr. Anthony Fauci, chief medical adviser to the White House, said in August that the United States could be “problematic” if another mutation crossed the delta, national health care this summer. He called on unvaccinated people to fire in hopes of curbing the surge that disrupted the system. ..

DeltaPlus could also ultimately affect the age group eligible to receive Covid booster doses, said Dr. Peter Marks, a major Vaccine Regulator of the Food and Drug Administration, Wednesday night. rice field. The FDA and CDC have licensed Covid boosters for a variety of adults in the United States from all three US manufacturers (Moderna, Johnson & Johnson, Pfizer).

“The exact age is based on what we see about the new situation, which is currently very dynamic as reports of new variants continue to be seen,” Marks said. increase. “Also, there are now changes in the epidemiology of Covid-19 in our country, and new hotspots are emerging as certain locations decline.”

Concerns about Delta Plus are growing in the UK, where authorities are fighting a surge in incidents and a new health crisis. According to the latest data from the National Security Agency, DeltaPlus cases accounted for approximately 6% of all Covid cases sequenced as of the week beginning September 27. Authorities have pointed out that the frequency of sublineage is “increasing” in the UK, and doctors from the United Kingdom National Health Service in London are calling for a return to the stricter Covid protocol for the winter.

But global health leaders are calling on the public not to panic. The emergence of Covid subtypes is not the same as the evolving entirely new variant, but tracking the progression of the delta may help the medical community better understand mutations, Covid in the WHO region. -19 Incident Manager Dr. Sylvain Aldighieri The Americas branch said at a briefing on October 6.

“Looking at these additional changes may help researchers track variants in detail,” says Aldighieri. “But they do not mean a functional or biological difference.”

Holly Eliyat of CNBC in London contributed to this report.

U.S. officials are watching carefully for the “Delta Plus” mutation to spread to the UK

Source link U.S. officials are watching carefully for the “Delta Plus” mutation to spread to the UK

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