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A single dose of Johnson & Johnson may be essential for vaccination of the rest of the country. But did it miss a decisive moment?

With daily vaccinations declining across the United States for a month, the pitfalls of Johnson & Johnson’s single-dose vaccine deployment are millions of unused vaccinations, public skepticism, and national vaccine deployment. Has resulted in a diminished role in.

Johnson & Johnson aimed to deliver 100 million doses of vaccine to the state by the end of May, but CDC data show that less than 22 million vaccines have been shipped to the state so far. Shots currently account for less than 4% of nationally administered doses.

In Washington, supply shortages are reducing plans to target hard-to-reach communities and incorporate vaccines into the state’s larger deployments, said state health and welfare minister, Dr. Umair Shah.

“There were interruptions, concerns, and even pauses,” he said. “Therefore, we have not actually fulfilled the promise that we all would have wanted here for the J & J vaccine.”

This shortage is due, at least in part, to the major setbacks the company faced at the end of March, which revealed the need to dispose of batches of vaccine material. Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said Human Error contaminated and ruined 15 million doses at the Emergent BioSolutions plant in Maryland, causing regulators to shut down the production process. I told CBS.

On Friday, the FDA approved the use of two batches of vaccine drug substances manufactured at the Emergent plant. A source told CBS News that the authorization would release about 10 million doses for use in the United States and abroad.Facilities in East Baltimore One of three sites Used worldwide by Johnson & Johnson as the first step in vaccine production.

15 million doses of Johnson & Johnson vaccine spoiled by the Baltimore Institute's mistake
Exterior view of the Emergent BioSolutions plant in Baltimore, Maryland, April 1, 2021.

Tasoska Topodis / Getty Images


State and federal health authorities also had to face the hesitation of the public in two ways: effectiveness and safety. The company announced that despite all three vaccines successfully protecting against serious illness and death, the overall efficacy rate is low compared to the two mRNA candidates Pfizer and Moderna. .. It went back even further after the CDC and FDA suspended the use of the vaccine while the Federal Advisory Board was investigating rare cases of blood clots that occurred primarily in women under the age of 50. As mentioned above, a warning has been added to the vaccine label.

Despite health authorities supporting the safety and efficacy of vaccines, polls suggest that the message may not have resonated, especially among those who are already hesitant about vaccines. ..

In a March Kaiser Family Foundation poll, how others would get the vaccine before more than 50% of unvaccinated Americans said they would definitely or probably take the Johnson & Johnson vaccine. I want to wait for you to react to. However, in April after the suspension, only 28% of people in that category said they were very or somewhat confident in the safety of the vaccine.

Dr. Grace Lee, a member of the CDC Advisory Board that evaluated vaccine safety and chair of a workgroup within the Federal Advisory Board, said that suspension of vaccines could raise questions about vaccine safety. I admitted that there is. But she repeated the reaction repeated by health authorities across the country: its hard-working surveillance should generate credibility.

“It’s not about specific vaccine information, it’s about how we handle decisions about it,” she said.

Over the past few weeks, representatives of the State and Community Health Officials Association (ASTHO) have stated that member states have shelved vaccine doses, especially Johnson & Johnson doses, and the CDC and White House are approaching expiration dates. I’m discussing with. Dr. Nirav Shah, president of the organization and director of the US Centers for Disease Control and Prevention, told CBS News. The organization has sent a list of policy considerations that the government should consider, such as sending these doses abroad and working with the FDA to extend the expiration date of the vaccine.

On Thursday, Johnson & Johnson announced that it had extended the shelf life of vaccines by 50% from three months to four and a half years. Sources familiar with the matter told CBS News before the decision that hundreds of thousands of doses were nearing expiration.

Other states are considering options for J & J doses that they do not plan to use, but Dr. Umair Shah said he was optimistic and hesitant about future use.

“What I’m worried about is that the time I should have helped with the J & J vaccine has passed a little longer,” he said.

“We are committed to ending this deadly pandemic as quickly as possible,” the company said in a statement.

“We continue to work with the U.S. government and health authorities to support the use of vaccines. Vaccines continue to be important, including among those who wish to be fully vaccinated in one shot. It plays a role. ”

West Virginia Toyota Motor Plant Partners with State to Hold Employee Vaccination Event
The Covid-19 Johnson & Johnson Janssen Vaccine Box is part of a collaboration between the West Virginia National Guard, Family Care Health Center and Toyota to vaccinate Toyota employees on the premises of the Toyota plant on March 26, 2021. Ready to be distributed. In Buffalo, West Virginia.

STEPHEN ZENNER / Getty Images


The time when the vaccine makes the biggest dents may be gone, but it is still important in some situations, such as when it is difficult to schedule a second dose. According to a CDC survey conducted in April during the suspension, more than 50% of US states and territories are homeless individuals, people behind bars, or people who can’t leave home. I was using the J & J vaccine to inoculate.

Dr. Nirav Shah states that there continues to be “strong demand” for shots through mobile vaccination units in his state. His strategy to maintain its use was to maximize convenience and provide on-site physicians to answer patient questions.

“Of course, it’s more focused, not 1,000 or 3,000 a day. It’s okay. You don’t have to,” he said in an interview last month. “But I think it’s the key to those who are motivated by convenience or are asking serious questions.”

Convenient elsewhere in the country, including northwestern India, where Beth Wrobel, CEO of HealthLinc, a local community health center, states that he used the J & J vaccine at vaccine events at about 10 different manufacturing sites in the region. Gender is prioritized. Tom Dermody, Mayor of Laport, Indiana, said he partnered with the clinic to administer the vaccine in the town, but for some people a single-dose vaccine is still ideal. However, both authorities have revealed that demand is undoubtedly declining.

Dr. Umair Shah emphasizes that J & J vaccines continue to be an attractive option for those facing more barriers to vaccination, as the pool of individuals who do not want to be vaccinated continues to decline. Did.

“This is where the one-shot vaccine is very useful. If you had it all the time, it would be even more useful,” he said.

Alexander contributed to the report.

A single dose of Johnson & Johnson may be essential for vaccination of the rest of the country. But did it miss a decisive moment?

Source link A single dose of Johnson & Johnson may be essential for vaccination of the rest of the country. But did it miss a decisive moment?

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